Potential Side Effects of Long-Term Use of Mushroom Supplements

Mushroom supplements are all the rage these days, and for good reason! They offer a host of health benefits, from boosting your immune system to enhancing cognitive function. But like anything, moderation is key. Let’s take a closer look at some potential side effects of long-term use of these popular supplements.

The Good and the Not-So-Good

1. Cognitive Function:

• The Good: Mushrooms like Lion’s Mane (Hericium erinaceus) are known for their brain-boosting properties. They can improve cognitive function and may even reduce the risk of neurodegenerative diseases.
• The Not-So-Good: Long-term use might lead to imbalances in gene expression related to memory and anxiety, at least according to some animal studies (Fijałkowska et al., 2023).

2. Allergic Reactions and Gastrointestinal Issues:

• The Good: Most people tolerate mushroom supplements well.
• The Not-So-Good: If you’re sensitive, you might experience allergic reactions or digestive issues like bloating and diarrhea. Always start with a small dose to see how your body reacts.

3. Serious Adverse Reactions:

• The Good: Medicinal mushrooms are generally safe when used correctly.
• The Not-So-Good: Misuse of certain mushrooms, especially “magic mushrooms,” can lead to severe health issues like rhabdomyolysis and renal failure. But don’t worry, these cases are usually related to their hallucinogenic properties, not common medicinal use (Bickel et al., 2005).

4. Immune System Effects:

• The Good: Mushrooms like Pleurotus ostreatus have immunomodulatory effects, which can be great for boosting your immune system.
• The Not-So-Good: Prolonged use might alter immune system function, so it’s something to keep an eye on (Bergendiova et al., 2011).

Conclusion

While mushroom supplements can be a fantastic addition to your wellness routine, it’s important to be aware of potential side effects, especially with long-term use. Always consult with a healthcare provider before starting any new supplement, and monitor how your body responds over time.

Have you tried mushroom supplements? What has your experience been like? Share your thoughts in the comments below!

Read further:

1. Fijałkowska, A., Rychlik, M., Krakowska, A., & Muszyńska, B. (2023). Effects of Dietary Supplementation with In Vitro-Cultivated Arboreal Medicinal Mushrooms on Long-Term Memory and Anxiety-Like Behavior of Male Mice. International Journal of Medicinal Mushrooms. Link to paper

2. Bickel, M., Ditting, T., Watz, H., Roesler, A., Weidauer, S., Jacobi, V., Gueller, S., Betz, C., Fichtlscherer, S., & Stein, J. (2005). Severe rhabdomyolysis, acute renal failure, and posterior encephalopathy after ‘magic mushroom’ abuse. European Journal of Emergency Medicine. Link to paper

3. Bergendiova, K., Tibenska, E., & Majtan, J. (2011). Pleuran (\β-glucan from Pleurotus ostreatus) supplementation, cellular immune response, and respiratory tract infections in athletes. European Journal of Applied Physiology. Link to paper